[10月17日]多肽药物研发导向的若干不对称催化反应研究

报告题目：多肽药物研发导向的若干不对称催化反应研究

报 告 人：张根 博士（兰州大学）

报告时间：2012年10月17日（星期三）上午10：00

报告地点：独墅湖校区二期云轩楼2301室

张根博士简介
教育背景
2004.9－2008.7 就读于兰州大学化学化工学院，获学士学位
2008.9至今     兰州大学化学化工学院有机化学硕博联读研究生

SCI期刊文章
1. Catalytic Asymmetric Activation of a Csp3-H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives
Gen Zhang, Yaohu Zhang and Rui Wang, Angew. Chem. Int. Ed. 2011, 50, pp10429-10433. Highlighted by Synfacts 2012, 8(1), 0072

2. Enantioselective Metal/Organo-Catalyzed Aerobic Oxidative sp3 C-H Olefination of Tertiary Amines Using Molecular Oxygen as the Sole Oxidant
Gen Zhang, Yunxia Ma, Shoulei Wang, Yaohu Zhang, and Rui Wang, J. Am. Chem. Soc. 2012, 134, 12334−12337 (“Most Read Articles” of JACS, Highlighted by Synfacts 2012, 8(10), 1118)

3. One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent
Gen Zhang, Yaohu Zhang, Jiexi Yan, Ru Chen, Shoulei Wang, Yunxia Ma, and Rui Wang, J. Org. Chem. 2012, 77, 878−888. Highlighted by Synfacts 2012, 8(5), 0468

4. Highly Enantioslective Synthesis of Multisubstituted Polyfunctional Dihydropyrrole via an Organocatalytic Tandem Michael/Cyclization Sequence
Gen Zhang, Yaohu Zhang, Xianxing Jiang, Wenjin Yan, and Rui Wang, Org. Lett. 2011, 13 (15), pp 3806–3809

5. Enantioselective Synthesis of Cyclic Thioureas via Mannich Reaction and Concise Synthesis of Highly Optically Active Methylthioimidazolines: Discovery of a More Potent Antipyretic Agent
Xianxing Jiang1, Yiqing Wang1, Gen Zhang, Dan Fu, Futing Zhang, Ming Kai and Rui Wang, Adv. Synth. Catal. 2011, 353, 1787-1796

6. Direct Organocatalytic Asymmetric Aldol Reaction of α-Isothiocyanato Imides to α-Ketoesters under Low Ligand Loading: A Doubly Stereocontrolled Approach to Cyclic Thiocarbamates Bearing Chiral Quaternary Stereocenters
Xianxing Jiang, Gen Zhang, Dan Fu, Yiming Cao, Fangfang Shen, and Rui Wang，Org. Lett. 2010,12, 1544-1547

7. Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts
Xianxing Jiang, Dan Fu, Gen Zhang, Yiming Cao, Luping Liu, Jingjing Song and Rui Wang, Chem. Commun. 2010, 46, 4294–4296

8. Doubly Stereocontrolled Asymmetric Aza-Henry Reaction with in situ Generation of N-Boc-Imines Catalyzed by Novel Rosin- Derived Amine Thiourea Catalysts
Xianxing Jiang1, Yifu Zhang1, Lipeng Wu, Gen Zhang, Xing Liu, Hailong Zhang, Dan Fu, and Rui Wang, Adv. Synth. Catal. 2009, 351, 2096-2100

9. Enantio- and Diastereoselective Asymmetric Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes in a Doubly Stereocontrolled Manner Catalyzed by Bifunctional Rosin-Derived Amine Thiourea Catalysts
Xianxing Jiang, Yifu Zhang, Xing Liu, Gen Zhang, Luhao Lai, Lipeng Wu, Jiannan Zhang, and Rui Wang, J. Org. Chem. 2009, 74, 5562–5567