[5月10日]From Diversity in Small Molecule Synthesis to Carbohydrate-based Vaccines: Concerted Efforts towards Eradicating Cancer

报告题目：From Diversity in Small Molecule Synthesis to Carbohydrate-based Vaccines: Concerted Efforts towards Eradicating Cancer

报 告 人：Peter R. Andreana (美国韦恩州立大学化学系 Assistant Professor)

报告时间：2012年5月10日（星期四）上午9:00

报告地点：独墅湖校区二期云轩楼1319室

Research experience:

Harvard University  10/2002 – 07/2005

• Synthesis of skeletally diverse small molecule library using Lanterns® and MacroBeads®

• Employed Diversity Oriented Synthesis (DOS) for the construction of a 4CCR/IMDA library with a diverse skeletal array

• Developed a chiral Zr(IV) Lewis acid for a catalytic asymmetric Ugi reaction

• Developed a chiral Cu(II) Lewis acid for a catalytic asymmetric Passerini reaction

• Contributing author on successful 2003 NIH-CMLD center grant

Wayne State University   09/1998 – 10/2002

• Synthesized natural and unnatural sugars employing RCM

• Developed a one-pot chemo-enzymatic synthesis of 7-membered polyhydroxyazepanes

• Developed a chemo-enzymatic combinatorial carbohydrate library of α-gal epitopes in solution phase and on solid support

• Examined conformationally constrained α-gal epitopes

• Contributing author on successful 1998 WSU Prostate Initiative grant: “Development of Prostate-Specific Antitumor Agents”

PUBLICATIONS:

1. Santra, S.; Andreana, T. L.; Andreana, P. R. (2011) Recent Advances of Convertible Isocyanides: Application in Small Molecule Synthesis and Drug Discovery. Submitted (PI).

2. De Silva, R. A; Appulage, D. K., Media, J.; Andreana, P. R. (2011) The Entirely Carbohydrate Immunogen Tn-PS A1 Induces a Cancer Cell Selective Immune Response and Cytokine IL-17. Submitted (PI).

3. Abu-Soud, H. M.; Maitra, D.; Byun, J.; Souza, C. E. A.; Banerjee, J.; Andreana, P. R.; Pennathur, S. (2011) The Reaction of HOCl and Cyanocobalamin: Corrin Destruction and the Liberation of Cyanogen Chloride. Free Radical Biology and Medicine Accepted (Co-PI).

4. Santra, S.; Andreana, P. R. (2011) A Bioinspired Ugi/Michael/aza-Michael Cascade Reaction in Aqueous Media: Natural Product-Like Molecular Diversity. Angewandte Chemie International Edition DOI: 10.1002/anie.201103567. Designated as Hot Paper (PI).

5. Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Diamond, M. P.; Saed, G. M.; Pennathur, S.; Abu-Soud, S. M. (2011) Reaction of Hemoglobin with HOCl: Mechanism of Heme Destruction and Free Iron Release. Free Radical Biology and Medicine 51: 374-386. (Co-PI).

6. Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Saed, G. M.; Diamond, M. P.; Pennathur, S.; Abu-Soud, S. M. (2011) Mechanism of Hypochlorous Acid-Mediated Heme Destruction and Free Iron Release. Free Radical Biology and Medicine 51: 364-373. (Co-PI).

7. Santra, S.; Jonas, E.; Bourgault J.-P.; El-Baba, T; Andreana, P. R. (2011) Kinetic Products Under Thermal Conditions: Rapid Entry into Anomeric Substituted α/β-D-Galactofuranosides Using Microwave Irradiation and Selective Lewis Acids. Journal of Carbohydrate Chemistry 30: 27-40. (PI).

8. Santra, S.; Andreana, P. R. (2011) A Rapid, One-Pot, Microwave-Influenced Synthesis of Spiro-2,5-Diketopiperazines via a Cascade Ugi/6-exo-trig aza-Michael Reaction. Journal of Organic Chemistry 76: 2261-2264. (PI).

9. De Silva, R. A.; Wang, Q.; Chidley, T.; Appulage, D. K.; Andreana, P. R. (2009) Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn-PS A1 Conjugates. Journal of the American Chemical Society 131: 9622-9623. (PI).

10. Yatawara, A. K.; Tiruchinapally, G.; Bordenyuk, A. N.; Andreana, P. R.; Benderskii, A. V. (2009) Carbohydrate Surface Attachment Characterized by Sum Frequency Generation Spectroscopy. Langmuir 25: 1901-1904. (Co-PI).