蒋小岗

电子邮箱：jiangxiaogang@suda.edu.cn

教育与工作经历：

1999年7月毕业于苏州医学院（现苏州大学苏州医学院）；

2004年7月获苏州大学药理学硕士学位；

2007年7月获中科院大连化学物理研究所分析化学博士学位；

1999年8月进入苏州医学院（现苏州大学苏州医学院）药理学系工作至今。

研究方向：肺纤维化药理与毒理

1. 肺成纤维细胞分化的药物干预及其机制研究

2. 肺毒性药物致肺泡上皮细胞损伤的机制研究

授权专利：

野马追倍半萜内酯在制备预防或治疗肺纤维化药物中的应用

专利号：ZL 2022 1 0081704.0

发表论文：

1. Xionghua Sun, Mei Zhu, Wei Xia, Xihan Xu, Jian Zhang^*, Xiaogang Jiang^*. Total sesquiterpenoids from Eupatorium lindleyanum DC. attenuate bleomycin-induced lung fibrosis by suppressing myofibroblast transition. Fitoterapia, 2023, 169, 105567

2. Xionghua Sun, Xiaogang Jiang*. Collagen targeting liposomes, a promising strategy for idiopathic pulmonary fibrosis. Journal of Controlled Release, 2023, https://doi.org/10.1016/j.jconrel.2023.01.005.

3. Xionghua Sun, Xiaogang Jiang*. Comment on “Reactive oxygen species-responsive polypeptide drug delivery system targeted activated hepatic stellate cells to ameliorate liver fibrosis”. ACS nano, 2023, 17, 4094-4095.

4. Lengqiu Guo, Yun Yang, Jie Yuan, Huiling Ren, Xiaolei Huang, Meng Li, Long Xia, Xiaogang Jiang*, Daofeng Chen*, Jian Zhang*. Da-Yuan-Yin decoction polyphenol fraction attenuates acute lung injury induced by lipopolysaccharide. Pharmaceutical Biology, 2023, 61, 228–240.

5. 朱媚，蒋小岗*. 肺肌成纤维细胞转化的研究新进展. 中国药理学通报，2023, 39, 1-4.

6. Mei Zhu, Jian Zhang, Xionghua Sun*, Xihua Chen, Xiaogang Jiang*. Eupafolin suppresses TGF-β1-induced human lung fibroblasts differentiation by downregulating β-catenin/plasminogen activator inhibitor-1 signaling. Pharmacological Research-Modern Chinese Medicine, 2022, 2, 100056.

7. Meng Li, Yadong Cui,Mei Zhu, Xiaolei Huang, Faiz UrRehmana, Jingwen Wang,  Lixiao Zhang, Tianwen Liu, Jiangyun Liu, Junye Lu, Xiaogang Jiang*, Jian Zhang*. Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays. Fitoterapia. 2022, 156, 105100.

8. Xiafang Xu, Xionghua Sun, Xuelei Wan, Xihua Chen, Xiaogang Jiang*. Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling. Toxicology Letters, 2021, 352, 61-69.

9. 朱含月，朱媚，陈喜华，蒋小岗*. 蓝萼甲素下调GSK3β/β-catenin信号通路抑制TGF-β1诱导的肺成纤维细胞转化. 药学学报，2021，56，2950-2956.

10. Xionghua Sun, Mei Zhu, Xihua Chen, Xiaogang Jiang*.MYH9 inhibition suppresses TGF-β1-stimulated lung fibroblast-to-myofibroblast differentiation.Frontiers in Pharmacology,2021, 11, 573524.

11. Xionghua Sun, Xinjian Cui, Xihua Chen, Xiaogang Jiang*.Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor. Biomedicine & Pharmacotherapy,2020, 131, 110744.

12. Fanqing Lu, Xionghua Sun, Xiafang Xu, Xiaogang Jiang*.SILAC-based proteomic profiling of the suppression of TGF-β1-induced lung fibroblast-to-myofibroblast differentiation by trehalose. Toxicologyand Applied Pharmacology, 2020, 391, 114916.

13. Xinjian Cui, Xionghua Sun, Fanqing Lu, Xiaogang Jiang*. Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21. Toxicologyand Applied Pharmacology,2018, 358, 35-42.

14. Xiang Zhou, Xionghua Sun, Xiaogang Jiang*. Comparative proteome profiling of bleomycin-induced lung toxicity in rats by 2D-nano-LC-MS/MS and spectral counting. Biomedical Chromatography, 2017, 31，e3857.

15. Xionghua Sun, Xiaogang Jiang*.Automated platform of μLC-MS/MS using SAX trap column for highly efficient phosphopeptide analysis. Analytical and Bioanalytical Chemistry,2017, 409, 2489-2493.

16. 周艳卿，蒋小岗*. Edman降解中异硫氰酸苯酯新修饰位点的发现和验证. 色谱，2016，34，752-756.

17. Yan Gao, Jia Lu, Yu Zhang, Yafen Chen, Zhenlun Gu, Xiaogang Jiang*. Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulmonary Pharmacology & Therapeutics, 2013, 26, 649-654.

18. Xionghua Sun, Xiaogang Jiang*.Combination of FASP and fully automated 2D-LC-MS/MS allows in-depth proteomic characterization of mouse zymogen granules. Biomedical Chromatography, 2013, 27, 407-408.